Table 3.
Correlation between the glucose, lipid, and water-electrolyte metabolism data and gut microbiota in different groups.
| Subjects | Phylum | Class | Order | Family | Genus | Species |
|---|---|---|---|---|---|---|
| NAFL versus controls | Verrucomicrobia↓ (TG r = −0.266) | Verrucomicrobiae↓ (TG r = −0.266) | Verrucomicrobiales↓ | Akkermansiaceae↓ | Akkermansia↓ | NA |
| (TG r = −0.266) | (TG r = −0.266) | (TG r = −0.266) | ||||
| Pasteurellales↓ (DBP r = 0.257, body fat mass r = -0.229, total body water r = −0.237) | Pasteurellaceae↓ (DBP r = 0.257, body fat mass r = −0.229, total body water r = −0.237) | Haemophilus↓ (DBP r = 0.259, body fat mass r = −0.230, total body water r = −0.239) | ||||
| Staphylococcaceae↑(visceral fat r = 0.239, Chol r = −0.310, LDL-C r =−0.390) | ||||||
| NASH versus controls | NA | NA | Bacillales↑ (body fat mass r = 0.319, visceral fat r = 0.325, Chol r = −0.271, LDL-C r = −0.292) | Rikenellaceae↓ (visceral fat r = 0.244, percent body fat r = 0.262, HB r = −0.268, HbA1c r = −0.244) | Faecalibacterium↓ (intracellular fluid r = −0.242, inorganic salt r = −0.254, total body water r = −0.229) | Roseburia_inulinivorans ↓ (HB r = −0.339, HbA1c r = −0.237) |
| Roseburia↓ (HB r = −0.359, HbA1c r = −0.277) | Bifidobacterium_adolescentis ↓ (TG r = 0.424, Chol r = 0.363, LDL-C r = 0.372) | |||||
| Parabacteroides_merdae ↓ (HB r = −0.231, HbA1c r = −0.267) | ||||||
| Coprococcus_comes ↓ (Glu r = −0.472) | ||||||
| NASH versus NAFL | NA | NA | NA | Rikenellaceae↓ (visceral fat r = 0.244, percent body fat r = 0.262, HB r = −0.268, HbA1c r = −0.244) | Roseburia↓ (HB r = −0.359, HbA1c r = −0.277) | Roseburia_inulinivorans ↓ (HB r = −0.339, HbA1c r = −0.237) |
| Marinifilaceae↓ (visceral fat r = 0.251, percent body fat r = 0.247) | Alistipes↓ (visceral fat r = 0.246, percent body fat r = 0.228, HB r = −0.278, HbA1c r = −0.239) | Parabacteroides_merdae ↓ (HB r = -0.231, HbA1c r = -0.267) | ||||
| Roseburia_intestinalis ↓ (percent body fat r = 0.277, HB r = −0.297, HbA1c r = −0.302) |
SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Glu, glucose; TG, triglyceride; Chol, cholesterol; HB, hemoglobin; HbA1c, glycosylated hemoglobin; NA, not available; NAFL, nonalcoholic fatty liver; NASH, nonalcoholic steatohepatitis.