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. 2021 Oct 28;15:785433. doi: 10.3389/fncel.2021.785433

FIGURE 1.

FIGURE 1

Cumulative effect of inflamma-miRNAs on inflammatory signaling pathways. Multiple inflamma-miRNAs may play a synergistic role in different inflammatory pathways. For instance, miR-146a targets different components of the MyD88/TLR/NF-κB pathways and microglia polarization. MiR-155 targets SOCS1 and SHIP1, whereas miR-125b, miR-146a, miR-155, Let-7, and miR-181 regulate multiple inflammatory mediators. C/EBP transcription factors are important for various inflammatory processes such as M1/M2 polarization and are targeted by Let-7. C/EBP, CCAAT/enhancer-binding protein; DAMPs, damage-associated molecular patterns; IFR, interferon receptor; IRAK, interleukin 1 receptor-associated kinase; NF-κB, nuclear factor κB; TLRs, Toll-like receptors; TNF, tumor necrosis factor; TRAF, tumor necrosis factor receptor-associated factor.