Figure 2.

Potential therapeutic effects of extra-virgin olive oil (EVOO) on Alzheimer disease. Extra-virgin olive oil may help prevent and even halt the progression of Alzheimer disease by reducing β-amyloid (Aβ) deposits and tau neuropathologies by enhancing autophagy and clearance mechanisms across the blood-brain barrier. Extra-virgin olive oil reduces astrocyte and microglial cell activation by reducing inflammatory cytokine production. Extra-virgin olive oil’s widespread antioxidant effects may also lead to enhancement of brain antioxidant enzymes and a reduction in reactive oxygen species (ROS).