Skip to main content
. 2021 Oct 28;12:747958. doi: 10.3389/fneur.2021.747958

Table 3.

Causes of withdrawal or dose-reduction of the first antiseizure medication, n (%).

Allergy Ineffective Liver damage Other objective adverse effects Poor compliance Seizure-free for 3 y
Valproic acid 3 (9.4) 9 (28) 4 (13) 9 (28) 8 (19) 1 (3.1)
Carbamazepine 0 (0.0) 0 (0.0) 1 (25) 1 (25) 2 (50) 0 (0.0)
Oxcarbazepine 19 (19) 16 (16) 24 (25) 28 (29) 10 (10) 1 (1.0)
Topiramate 3 (21) 2 (14) 0 (0.0) 6 (43) 3 (21) 0 (0.0)
Levetiracetam 1 (3.8) 7 (26) 7 (26) 9 (33) 2 (7.4) 1 (3.7)
Phenobarbital 0 (0.0) 1 (50) 1 (50) 0 (0.0) 0 (0.0) 0 (0.0)
Lamotrigine 1 (17) 3 (50) 1 (17) 0 (0.0) 1 (17) 0 (0.0)
Othersa 0 (0.0) 0 (0.0) 0 (0.0) 1 (100) 0 (0.0) 0 (0.0)
a

“Others” refers to pregabalin and gabapentin.