Table 3.
Causes of withdrawal or dose-reduction of the first antiseizure medication, n (%).
| Allergy | Ineffective | Liver damage | Other objective adverse effects | Poor compliance | Seizure-free for 3 y | |
|---|---|---|---|---|---|---|
| Valproic acid | 3 (9.4) | 9 (28) | 4 (13) | 9 (28) | 8 (19) | 1 (3.1) |
| Carbamazepine | 0 (0.0) | 0 (0.0) | 1 (25) | 1 (25) | 2 (50) | 0 (0.0) |
| Oxcarbazepine | 19 (19) | 16 (16) | 24 (25) | 28 (29) | 10 (10) | 1 (1.0) |
| Topiramate | 3 (21) | 2 (14) | 0 (0.0) | 6 (43) | 3 (21) | 0 (0.0) |
| Levetiracetam | 1 (3.8) | 7 (26) | 7 (26) | 9 (33) | 2 (7.4) | 1 (3.7) |
| Phenobarbital | 0 (0.0) | 1 (50) | 1 (50) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Lamotrigine | 1 (17) | 3 (50) | 1 (17) | 0 (0.0) | 1 (17) | 0 (0.0) |
| Othersa | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100) | 0 (0.0) | 0 (0.0) |
“Others” refers to pregabalin and gabapentin.