Table 3.
Overview of included systematic reviews on H1N1pdm09 vaccines according to outcome.
| OUTCOME | Reference | Total number of studies included a | Type of study | Meta-analyses by vaccine type (adjuvants yes/no) | Date of search |
|---|---|---|---|---|---|
| Short term adverse events (mild/mod/serious) | |||||
| All types | Manzoli, (26) | 18 | RCT | Yes | Apr. 2011 |
| Effect of adjuvants, pediatric (all types) | Stassijns, b (33) | 8 | RCT | Yes | Apr. 2015 |
| Effect of adjuvants, pediatric/adults (mild only) | Hauser, (25) | 22c | RCT | Yes | Sep. 2018 |
| Narcolepsy | Sarkanen, (32) | 11 | Observational studies | Yes | Nov. 2016 |
| Demicheli, (20) | 4 | No | Dec. 2016 | ||
| Guillain-Barré syndrome (GBS) | Sanz Fadrique, d (31) | 2 | Observational studies | No | Jul. 2017 |
| Martin Aries, (27) | 16 | Yes | Apr. 2014 | ||
| Demicheli, (20) | 2 | No | Dec. 2016 | ||
| Wachira, (34) | 15 | No | Jun. 2017 | ||
| Inflammatory bowel disease (IBD) | Pineton, (29) | 1 | Observational study | NA | Jun. 2014 |
| Demyelinating diseases | Demicheli, (20) | 1 | Observational study | NA | Dec. 2016 |
| Pregnancy- and fetal outcomes and offspring | |||||
| Adverse events in pregnancy (local, systemic, preeclampsia); congenital malformation; spontaneous abortion; still birth; preterm birth; small for gestational age (SGA); low birth weight | McMillan, (21) | 17 | Observational studies | No | Mar. 2014 |
| Preterm birth; late fetal death; any fetal death | Fell, (22) | 12 | Observational studies | No | May 2013 |
| Preterm birth; SGA; low birth weight | Nunes, (28) | 13 | Observational studies | No | Jun. 2015 |
| Congenital malformation | Polyzos, (30) | 12 | Observational studies | No | Dec. 2014 |
| Spontaneous abortion; fetal death; stillbirth; preterm birth; congenital malformations; neonatal death | Demicheli, (20) | 14 | Observational studies | No | Dec. 2016 |
| Congenital malformation; spontaneous abortion; still birth; preterm birth; SGA | Zhang, (35) | 19 | Observational studies | No | Jan. 2017 |
| Congenital malformation; stillbirth/fetal death; SGA; low birth weight | Giles, (24) | 9 | Observational studies | Yes | May 2017 |
| Early childhood health outcomes | Foo, (23) | 6 | Observational studies | No | Jul. 2019 |
a
studies from which data extraction on H1N1pdm09 vaccination was possible (i.e. not pooled with seasonal influenza vaccination). In systematic reviews covering more than one outcome, the number of studies may be lower for single outcomes. bstudies also included in Hauser et al. (25). cunclear if all studies reported adverse events. dupdate of Martin Aries et al. (27).