Table 4.
Systematic review of vaccination with Pandemrix and risk of narcolepsy.
| Children and adolescents | Adults | |||||
|---|---|---|---|---|---|---|
| Number of studies | Effect size (95% CI) | I2 | Number of studies | Effect size (95% CI) | I2 | |
| Index date a | ||||||
| Onset date | 6 | 14.32 (8.92, 22.99) | 0.0% | 3 | 7.01 (3.40, 14.46) | 0.0% |
| Healthcare contact | 3 | 9.68 (4.88, 19.23) | 44.1% | 3 | 8.08 (3.86, 16.89) | 0.0% |
| Diagnosis | 5 | 5.02 (3.36, 7.51) | 0.0% | 4 | 2.95 (1.88, 4.62) | 0.0% |
a
Exact date of symptom onset is difficult to remember and prone to recall bias. The studies used different index dates as proxy of disease onset. Some studies are included in analyses of more than one index date.