Table 5.
Adjusted estimates for fetal outcomes after maternal H1N1pdm09 vaccination.
| Outcome/ Systematic review | Vaccine adminstrated | Congenital malformations | Spontaneous abortion | Stillbirth/Fetal death/Abortion | Preterm delivery (< 37 weeks) | Small for gestational age birth (SGA) | Low birth weight (LBW) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Studies | Effect size (95% CI) | I2 | Studies | Effect size (95% CI) | I2 | Studies | Effect size (95% CI) | I2 | Studies | Effect size (95% CI) | I2 | Studies | Effect size (95% CI) | I2 | Studies | Effect size (95% CI) | I2 | ||
| Fell (22) | Any trimester | 3 | Range 0.56-0.79 a | 10 | No association a | ||||||||||||||
| Range 0.89-1.23ab | |||||||||||||||||||
| Range 0.44-0.77ac | |||||||||||||||||||
| McMillan ( 21 ) | Any trimester | 7 | No association a | 5 | No association a | 9 | No pooled estimate | 6 | OR = 0.93 (0.83-1.04) | 59% | 2 | OR = 0.91 (0.87-0.96) | 0% | 6 | OR = 0.94 (0.82-1.08) | 39% | |||
| 3 | HR = 1.00 (0.93-1.07)d | 0% | |||||||||||||||||
| Any trimester | 2 | OR = 0.79 (0.61-1.01)e | 19% | ||||||||||||||||
| Polyzos ( 30 ) | Any trimester | 10 | OR = 1.02 | ||||||||||||||||
| (0.91-1.14) | |||||||||||||||||||
| First trimester | 6 | OR = 1.02 | |||||||||||||||||
| (0.89-1.17) | |||||||||||||||||||
| Nunes ( 28 ) | Any trimester | 9 | OR = 0.90 (0.82-0.99) | 72% | 6 | OR = 0.98 (0.91-1.07) | 54% | 7 | OR = 0.88 (0.79-0.98) | 62% | |||||||||
| Zhang ( 35 ) | Any trimester | 6 | OR = 1.14 | 0% | 3 | OR = 1.04 | 0% | 10 | OR = 0.80 | 8% | 12 | RR = 0.92 | 68% | 7 | OR = 0.98 | 45% | |||
| (1.01-1.29) | (0.72-1.52) | (0.69-0.92) | (0.84-1.01) | (0.91-1.06) | |||||||||||||||
| First trimester | 2 | OR = 1.07 | 0% | ||||||||||||||||
| (0.59-1.94) | |||||||||||||||||||
| Demicheli ( 20 ) | Any trimester | 6 | OR = 1.11 | 0% | 5 | OR = 0.75 | 0% | 7 | OR = 0.84 | 71% 59% | |||||||||
| (0.99-1.23) | 3 | (0.62-0.90)f | 2 | (0.76-0.93) | |||||||||||||||
| HR = 0.81 | HR = 1.11d | ||||||||||||||||||
| (0.63-1.04)df | 0% | (0.46-2.68) | |||||||||||||||||
| Second/third trimester | 2 | OR = 1.08 | 0% | ||||||||||||||||
| (0.92-1.28) | |||||||||||||||||||
| First trimester | 2 | OR = 0.96 | 0% | ||||||||||||||||
| (0.87-1.90) | |||||||||||||||||||
| Giles ( 24 ) | Any trimester | 7 | OR = 1.03 (0.99-1.07) | 0% | 3 | OR = 0.84 | 0% | ||||||||||||
| (0.65-1.08) | |||||||||||||||||||
| Second/third trimester | 1 | HR = 0.96 (0.29-3.12) | 3 | OR = 0.96 (0.87-1.06) | 0% | 3 | OR = 0.96 (0.89-1.04) | 0% | 2 | OR = 0.97 (0.71-1.32) | 83% | ||||||||
| First trimester | 1 | HR = 1.32 (0.78-2.21) | 2 | OR = 1.08 (0.92-1.28) | 0% | 2 | OR = 1.00 (0.80-1.24) | 0% | |||||||||||
a
no pooled estimate, and no I2 blate fetal death cearly fetal death dseparate analysis on time metric and calculated HR e <32 weeks fabortion included spontaneous, internal, foetal death and stillbirth.