Table 3.
Represents the ADMET properties of lead compounds selected from the bulk of dietary polyphenols used in this virtual screening. C-1= Ellagic Acid; C-2= Kievitone; C-3 = Punicalin C-4= Remdesivir.
| Absorption&Distribution | C-1 | C-2 | C-3 | C-4 |
|---|---|---|---|---|
| BBB (+/-) | – | – | – | + |
| p-glycoprotein substrate | – | – | – | + |
| HIA+ | + | + | + | + |
| Metabolism | ||||
| CYP450 2C19 Inhibitor |
– | + | – | – |
| CYP450 1A2 Inhibitor |
– | + | – | – |
| CYP450 3A4 Inhibitor |
– | – | – | – |
| CYP450 2C9 Inhibitor |
– | + | – | – |
| CYP450 2D6 Inhibitor |
– | – | – | – |
| Excretion | ||||
| Biodegradation | – | – | – | – |
| Toxicity | ||||
| AMES Mutagenesis | – | – | + | – |
| Acute Oral Toxicity | II | III | III | III |
| hERG Inhibition | – | – | + | – |
| Carcinogenicity | – | – | – | – |
| Hepatotoxicity | + | + | + | + |