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. 2021 Jun 30;246(21):2259–2268. doi: 10.1177/15353702211023034

Figure 1.

Figure 1.

miR-296-5p was involved in ox-LDL-induced HUVEC injury. (a) miR-296-5p levels in HUVECs treated with ox-LDL at different concentrations (0, 10, 20, 40, or 80 µg/mL) for 48 h. **P < 0.01, ***P < 0.001 vs. 0 µg/mL. (b) miR-296-5p levels in HUVECs treated with 40 µg/mL ox-LDL for various durations (0, 12, 24, or 48 h). **P < 0.01, ***P < 0.001 vs. 0 h. (c) miR-296-5p levels in HUVECs transfected with the miR-296-5p agomir. ***P < 0.001 vs. agomir-NC. (d) miR-296-5p levels in HUVECs transfected with the miR-296-5p antagomir. ***P < 0.001 vs. antagomir-NC. (e) After transfection with the miR-296-5p agomir or miR-296-5p antagomir, HUVECs were treated with ox-LDL (40 µg/mL) for 48 h. A Cell Counting Kit-8 assay was used to detect the cell viability. **P < 0.001 vs. Blank; &&P < 0.001 vs. ox-LDL+ agomir-NC; ##P < 0.001 vs. ox-LDL+ antagomir-NC. (f) Cell apoptosis was evaluated using flow cytometry. **P < 0.01 vs. Blank; &&P < 0.01 vs. ox-LDL+ agomir-NC; ##P < 0.01 vs. ox-LDL+ antagomir-NC.