Figure 2.

Preliminary bioinformatic analysis about TMZ resistance based on GSE data. A. A total of 2121 DEGs that were identified in the merged datasets and the logical relations of them in GSE80729 and GSE43452; 1695 of those were from GSE80729 while the other 426 were from GSE43452; 1038 were upregulated and 1083 were downregulated. B. The KEGG pathway analyses of DEGs in merged datasets indicated that the key genes responding to TMZ treatment are possibly associated with signal transduction activity, p53 signaling pathways and multicellular organismal process. C. The GO analyses of DEGs in merged datasets indicated that the key genes responding to TMZ treatment are possibly associated with plasma membrane.