Table 1.
Metabolic pathways most affected by MFN2: p.Ile213Thr variant (in reverse order of comprehensive significance)
| KEGG (Kyoto Encyclopedia of Genes and Genomes) | Total | Hits | Raw P | Impact* |
|---|---|---|---|---|
| Sphingolipid metabolism | 21 | 3 | 0.003616 | 0 |
| Glycerophospholipid metabolism | 36 | 3 | 0.016662 | 0.21631 |
| Riboflavin metabolism | 4 | 1 | 0.060569 | 0.5 |
| Linoleic acid metabolism | 5 | 1 | 0.075153 | 0 |
| Amino sugar and nucleotide sugar metabolism | 37 | 2 | 0.11021 | 0.08314 |
| Ascorbate and aldarate metabolism | 8 | 1 | 0.11761 | 0 |
| alpha-Linolenic acid metabolism | 13 | 1 | 0.18426 | 0 |
| Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 14 | 1 | 0.197 | 0.00399 |
| Nicotinate and nicotinamide metabolism | 15 | 1 | 0.20955 | 0.23465 |
| Starch and sucrose metabolism | 18 | 1 | 0.24607 | 0.00974 |
| Pentose and glucuronate interconversions | 18 | 1 | 0.24607 | 0.07812 |
| Purine metabolism | 65 | 2 | 0.2665 | 0.00124 |
| Citrate cycle (TCA cycle) | 20 | 1 | 0.26951 | 0.09038 |
| Galactose metabolism | 27 | 1 | 0.34619 | 0.00228 |
| Alanine, aspartate and glutamate metabolism | 28 | 1 | 0.35649 | 0 |
| Glutathione metabolism | 28 | 1 | 0.35649 | 0.00709 |
| Glyoxylate and dicarboxylate metabolism | 32 | 1 | 0.39617 | 0.03175 |
| Arachidonic acid metabolism | 36 | 1 | 0.4335 | 0 |
| Arginine and proline metabolism | 38 | 1 | 0.45132 | 0 |
| Fatty acid degradation | 39 | 1 | 0.46003 | 0 |
*
Total, overall compound number within a pathway; Hits, the number of data matched with those uploaded by the user; Raw P, raw P-value determined based on enrichment analysis; Impact, impact value of the pathway determined through pathway topological analysis.