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Effect of varying doses of LDN193189 on tumor growth in C57BL/6 mice. Mice were injected with B16F10 cells (2 × 105) suspended in phosphate buffered saline (100 μL). Once the tumor reached a size of 100 mm3, control group was injected with normal saline, while treatment group was injected with BMP inhibitor LDN-193189 at different doses for 10 consecutive days (x-axis days 1 to 10). The values plotted are a mean of 3 animals in each group.
