Screening	Baseline6, 9, 11	Day 74	Day 144	Day 214	Day 282, 11	Day 42 1,4	Discharge10	Day 903	Unscheduled
Informed consent	X
Demographic data	X
Inclusion/exclusion criteria	X	X
HIV test^	X
Pregnancy test+	X5								X
Hepatitis B and C serology^	X
Genetic sequencing (PNPLA3)	X
Urinary ethyl glucuronide	X	X				X	X		X
Alcohol consumption	X					X	X		X
Duration since admission to hospital		X						X
Medical history	X
Prior/concomitant medications	X	X	X	X	X	X	X	X	X
Vital signs	X	X	X	X	X	X	X	X	X	X
Physical exam	X	X	X	X	X	X	X	X	X
Weight	X					X1		X	X
Height	X
Calorie and protein intake		X	X	X	X	X	X	X	X
Randomisation		X
IMP/placebo administration		X				X
Prothrombin time	X	X	X	X	X	X	X	X	X
Haematology%	X	X	X	X	X	X	X	X	X	X
Clinical chemistry%	X	X	X	X	X	X	X	X	X	X
Serum CK18-M30/M65 sample		X	X	X	X	X	X	X	X
DF, MELD, GAHS scores	X	X	X	X	X	X	X	X	X
Lille score			X
Overt GI haemorrhage assessment$	X	X	X	X	X	X	X	X	X
Acute kidney injury assessment$	X	X	X	X	X	X	X	X	X
EDTA sample for DNA (16S)	X	X	X	X	X	X			X
PBMC sample~		X	X	X		X			X
Infection/sepsis/SIRS screen	X	X	X	X	X	X	X	X	X	X
USS Liver assessment$	X
Fibroscan measurement$		X				X			X
Gene expression sample		X				X
Liver biopsy (incl. HVPG measurement*)8		X				X
Adverse events		X	X	X	X	X	X	X	X
PK/PD samples in blood and ascites fluid #		X	X	X	X	X	X	X	X
Biomarker serum		X	X	X	X	X	X	X	X
Stool and saliva sample		X		X		X			X