Table 3.

Research progress on ferroptosis in diffuse large B-cell lymphoma.

Researcher	Research object	Related Pathway	Target	Conclusions/ Results
Anja Schmitt (129)	GCB and ABC DLBCL cells	Lipid peroxidation	LOX/GSH/GPX4	Lipid peroxidation through the synergistic effect of high lipoxygenase expression and low levels of glutathione and glutathione peroxidase 4 in DLBCL due to DMF
Yan Zhang (130)	A DLBCL xenograft model (mice)	GSH synthesis pathway	System Xc-	Inhibition of the system Xc- and depletion of glutathione led to lipid peroxidation in DLBCL due to imidazole ketone erastin (IKE)
Yuko Kinowaki (131)	Cases of diffuse large B-cell lymphoma (patients)	Lipid peroxidation	GPX4	GPX4 knockdown induced cell lipid peroxidation in DLBCL
Wan Seok Yang (132)	Xenograft mouse tumor models/177 cancer cell lines	Lipid peroxidation	GPX4	In DLBLC, glutathione depletion resulted in the inactivation of glutathione peroxidase (GPXs) (overexpression and downregulation of GPX4)