Table 4.
Vaccines contraindicated during pregnancy
| Vaccine (platform) | Reason for contraindication | Safety considerations |
|---|---|---|
| BCG (live attenuated virus) | Contains live culture preparation of the BCG strain of Mycobacterium bovis | No harmful effects have been observed in pregnant women. However, safety in pregnancy has not been formally evaluated.162 |
| Human papilloma virus (recombinant virus-like particle) | No safety data available to support use in pregnancy. Not recommended by the CDC for administration during pregnancy. | No evidence of increased risk of adverse pregnancy or fetal outcomes following administration during pregnancy.163,164 If inadvertent administration during pregnancy, delay remaining doses until after pregnancy. |
| Measles, mumps, and rubella (live attenuated virus) | Contains live attenuated mumps, measles, and rubella viruses | No evidence of increased risk of adverse pregnancy or fetal outcomes (including congenital rubella syndrome) following administration during pregnancy.98 Pregnancy testing is not recommended before vaccine administration of vaccine. However, recipients are advised not to become pregnant for at least 28 days after vaccine dose.20,47 |
| Varicella (live attenuated virus) | Contains live attenuated varicella-zoster virus. | Data from Merck/CDC Pregnancy Registry have not identified any increased risk of congenital varicella syndrome.20,165 |
| Zoster (recombinant glycoprotein) | No safety data available to support use in pregnancy. Not recommended by CDC for administration during pregnancy. | Data from Merck/CDC Pregnancy Registry has not identified any increased risk of congenital varicella syndrome.20 |
BCG, Bacillus Calmette-Guérin; CDC, Centers for Disease Control and Prevention.
Etti. Maternal vaccination. Am J Obstet Gynecol 2022.