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. 2021 Nov 11;9:223. doi: 10.1186/s40168-021-01172-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Dietary fiber deficiency for 15 weeks altered synaptic proteome in the hippocampus. A–E The quantitative analysis of the global proteome of the hippocampus (n = 3). A Volcano plot of differentially expressed proteins. B Analysis of GO enrichment of biological process for differentially expressed proteins. C Analysis of KEGG pathway of the differentially expressed synaptic proteins. D The heatmap of the differentially expressed synaptic proteins. E PPI network analysis of distinctly dysregulated proteins based on STRING database and Cytoscape 3.6.0. Black lines denoted the interaction between two proteins. The red node signified up-regulation, blue node signified downregulation. F–H The verification of the quantitative analysis of the global proteome of the hippocampus for downregulated proteins (CaMKIId, GAP43, and SV2C) by western blot (n = 5–6). Values are mean ± SEM. *p < 0.05 fiber deficiency (FD) group vs. control (Con) group