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. 2021 Oct 28;12:705086. doi: 10.3389/fimmu.2021.705086

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Copyright © 2021 Qiu, Hu, Hu, Yu, Othmane, He, Ding, Cheng, Ren, Tan, Yu, Chen and Zu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of PMEPA1 on immunological status in pan-cancers using the TISIDB. (A, B) Correlation between PMEPA1 and 124 immunomodulators (chemokines, MHC-s, immune stimulators and receptors). (C) Correlation between PMEPA1 and 28 tumor-associated immune cells. The color indicates the correlation coefficient. The horizontal axis represents different tumor tissues, and the vertical axis represents the expression of immunomodulators and the infiltration levels of immune cells. (D) PMEPA1 mRNA expression in different immune subtypes in BLCA, C1 (would healing); C2 (IFN-gamma dominant); C3 (inflammatory); C4 (lymphocyte depleted); C5 (immunologically quiet); C6 (TGF-b dominant). (E) Correlation between PMEPA1 and eight immune checkpoints, which were obtained from TIMER database. The horizontal axis represents the expression of immune checkpoint-related genes and the vertical axis represents different tumor tissues. Red color indicates positive correlation, blue color indicates negative correlation, and white color indicates no statistical significance.