Table 3.

BKI potential uses: Animal Health

Treatment of sick calves: cryptosporidiosis/scours Moderate/severe crypto → sustained growth detriment, 34 kg average (Hannah Shaw, Moredun Univ) (Shaw, 2017) Proof-of-Concept (POC) calves, Michael Riggs (Univ. of AZ) (Hulverson et al., 2017b; Schaefer et al., 2016)

Cryptosporidium metaprophylaxis: prevent disease on contaminated farms Get calves to milk/market earlier & establish immunity POC calves, Jennifer Zambriski (Virginia Tech) (Unpublished)

Therapy or prophylaxis of Neospora caninum: epidemic abortion in cattle Eliminate need for culling POC pregnant mice, Andrew Hemphill (Univ. of Bern) (Muller et al., 2017a; Winzer et al., 2015) POC pregnant sheep, Luis Ortega-Mora (UCM) (Sanchez-Sanchez et al., 2018a; Sánchez-Sánchez et al., 2018)

Active low nM: Toxoplasma gondii: a frequent cause of sheep/goat abortions POC pregnant sheep, Luis Ortega-Mora (UCM) (Sánchez-Sánchez et al., 2019)

Prophylactic treatment of felines for T. gondii to prevent feline-derived T. gondii infection?

Active low nM on Sarcocystis neurona: Equine protozoal myeloencephalitis (EPM) in the Americas POC in mice, J.P. Dubey/Dan Howe (Univ of KY)(Ojo et al., 2016)

Active low nM: Cystoisospora suis: epidemic diarrhea in piglets POC in infected piglets, Anja Joachim (Vetmeduni, Vienna) (Shrestha et al., 2019; Shrestha et al., 2020)

Active low nM on Besnoiti besnoiti: cattle disease in Europe/Central Asia, skin and systemic damage POC in vitro, Gema Álvarez-García (UCM) (Jimenez-Melendez et al., 2017)