Table 2.
Median biomarker concentration values at preoperative, and change from preoperative baseline to postoperative day 1 and 3 by delirium status
| Biomarker | No Delirium | Delirium | P-valuea | ||
|---|---|---|---|---|---|
| N | Median (IQR) | N | Median (IQR) | ||
| Preoperative | |||||
| S-100β | 42 | 0.2 (0.2, 0.4) | 23 | 0.2 (0.1, 0.3) | 0.560 |
| CRP | 45 | 0.9 (0.6, 2.7) | 26 | 0.8 (0.7, 5.4) | 0.862 |
| IGF1 | 45 | 97.9 (64.2, 133.4) | 26 | 95.0 (69.8, 128.5) | 0.863 |
| IL-8 | 44 | 15.5 (9.4, 30.9) | 26 | 13.3 (8.9, 21.6) | 0.372 |
| IL-10 | 45 | 2.3 (1.5, 10.8) | 26 | 1.5 (1.5, 7.8) | 0.653 |
| TNFA | 44 | 12.3 (8.2, 19.9) | 26 | 12.3 (8.2, 16.8) | 0.908 |
| Change from preoperative to POD1 b | |||||
| S-100β | 42 | 1.0 (0.7, 1.5) | 23 | 1.3 (0.8, 1.6) | 0.414 |
| CRP | 45 | 16.8 (0.2, 35.4) | 26 | 30.2 (21.3, 43.9) | 0.050 |
| IGF1 | 44 | −5.1 (−29.2, 32.1) | 26 | −15.9 (−43.8, 0.0) | 0.113 |
| IL-8 | 44 | 24.8 (16.0, 41.7) | 26 | 38.6 (29.3, 69.8) | 0.022 |
| IL-10 | 45 | 12.4 (7.7, 25.7) | 26 | 26.1 (13.9, 36.7) | 0.025 |
| TNFA | 44 | 0.3 (−1.4, 4.1) | 26 | 3.0 (0.0, 10.0) | 0.066 |
| Change from preoperative to POD3 c | |||||
| S-100β | 36 | 0.5 (0.3, 0.8) | 22 | 0.5 (0.3, 0.9) | 0.695 |
| CRP | 39 | 40.4 (11.8, 49.2) | 25 | 32.9 (1.2, 44.6) | 0.193 |
| IGF1 | 38 | −33.0 (−61.3, −0.7) | 25 | −40.3 (−75.4, −26.5) | 0.199 |
| IL-8 | 39 | 11.7 (6.7, 22.8) | 25 | 17.2 (9.2, 23.0) | 0.160 |
| IL-10 | 39 | 0.4 (0.0, 6.4) | 25 | 2.9 (0.0, 8.2) | 0.231 |
| TNFA | 39 | 1.6 (−0.3, 6.7) | 25 | 1.6 (−0.5, 6.3) | 0.847 |
a
p values are from Wilcoxon rank sum test and unadjusted for other covariates. CRP: C-Reactive Protein; IGF: Insulin-like growth factor; IL: Interleukin; POD: Postoperative day; S100B: S100 Calcium Binding Protein B. TNFA: Tumor necrosis factor alpha.
b
Calculated as postoperative day 1 minus preoperative baseline;
c
Calculated as postoperative day 3 minus preoperative baseline.