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MT-associated Rac regulation of endothelial barrier function. HGF stimulation of EC induces Asef, a Rac-specific GEF, activation which undergoes peripheral translocation by forming a complex with MT protein APC. In turn, Asef associates with IQGAP1 at the cell periphery and activates Rac, resulting in enhanced endothelial barrier integrity. The upregulated endothelial barrier function inhibits agonists-induced vascular leak and inflammation.
