0-D |
No Dimension |
1-D |
One Dimension |
2-D |
Two-Dimension |
ABC |
ATP-Binding Cassette |
ABCB1 |
ABC Sub-Family B Member 1 |
ABCC1 |
ABC transporter C1 |
ABCG2 |
ABC transporter G2 |
ATM |
Ataxia-Telangiectasia Mutated |
ATR |
Ataxia–Telangiectasia and RAD3-Related |
AUC |
Area Under The Curve |
BAK |
Bcl-2 Homologous Antagonist Killer |
BAX |
Bcl-2-Associated X Protein |
BCL |
B cell lymphoma |
BCRP |
Breast Cancer Resistance Protein |
BH3 |
Bcl-2 Homology 3 |
BIND-014 |
PSMA-Targeted Docetaxel Nanoparticles |
CDK |
Cyclin-Dependent Kinase |
Chk2 |
Checkpoint Kinase 2 |
CL |
Clearance |
Cmax
|
Peak Drug Concentration |
COVID-19 |
Coronavirus Disease 2019 |
CR |
Complete Remission |
CYP |
Cytochrome P450 |
DDR |
DNA Damage Response |
DISC |
Death-Inducing Signaling Complex |
DNA |
Deoxyribonucleic Acid |
DR3 |
Death Receptor 3 |
EGFR |
Epidermal Growth Factor Receptor |
EPR |
Enhanced Permeability and Retention |
FADD |
Fas-Associated Protein With Death Domain |
FDA |
Food and Drug Administration |
GDP |
Guanosine 5′-Diphosphate |
GTP |
Guanosine 5′-Triphosphate |
IC50 |
Half-Maximal Inhibitory Concentration |
ID |
Injected Dose |
ILs |
Interleukins |
Lys |
Lysine |
MCL-1 |
Myeloid Cell Leukemia 1 |
MDR |
Multidrug Resistance |
MOMP |
Mitochondria Outer Membrane Permeabilization |
MRD |
Minimal Residual Disease |
MRE11 |
Meiotic Recombination 11 Homolog 1 |
MRI |
Magnetic Resonance Imaging |
MRN |
MRE11–RAD50–NBS1 |
mRNA |
Messenger Ribonucleic Acid |
MTD |
Maximum Tolerated Dose |
NLC |
Nanostructured Lipid Carriers |
NNI |
National Nanotechnology Initiative |
Orn |
Ornithine |
pCR |
Pathological Complete Response |
PEG |
Polyethylene Glycol |
Phe |
Phenylalanine |
PSMA |
Prostate Specific Membrane Antigen |
RAD50 |
Double Strand Break Repair Protein |
RB |
Retinoblastoma |
RES |
Reticuloendothelial System |
SAC |
Spindle Assembly Checkpoint |
SARS-CoV-2 |
Severe Acute Respiratory Syndrome Coronavirus 2 |
scFv |
Single Chain Fragment Variable |
SCLC |
Small Cell Lung Cancer |
SGT-53 |
Tumor Suppressor Gene TP53/scL-p53 |
SLN |
Solid Lipid Nanoparticles |
SN-38 |
7-Ethyl-10-Hydroxycamptothecin |
SN-38G |
SN-38 Glucuronide |
t
1/2
|
Elimination half-life |
TfR |
Transferrin Receptor |
TL1A |
TNF-Like Cytokine 1A |
TNF |
Tumor Necrosis Factor |
TOP1cc |
Topoisomerase I-DNA Cleaved Complexes |
Trp |
Tryptophan |
Tyr |
Tyrosine |
UGT1A |
Uridine Diphosphate Glucuronosyltransferase 1A |
Vd
|
Volume of Distribution |
VYXEOS |
Liposomal Cytarabine/Daunorubicin |