Figure 2.

Therapeutic strategy for locally advanced resectable OPSCC. ^a adverse pathological features include positive surgical margins; extracapsular spread; or combination of several pejorative criteria such as close surgical margins, perineural or vascular invasion, multiple/bilateral metastatic lymph nodes. ^b when tobacco consumption is greater than 10 pack-years, HPV-positive OPSCC could be managed as HPV-negative OPSCC. The preferred therapeutic option is in bold and underlined. Primary surgery is only considered if an acceptable functional outcome can be reasonably expected.