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. 2021 Oct 28;13(21):5418. doi: 10.3390/cancers13215418

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Diagram of the different cell sources used to obtain NK cells. These NK cells can be directly collected from Adult Peripheral Blood and Umbilical Cord Blood. They can be differentiated in vitro from CD34+ hematopoietic stem cells taken from umbilical cord blood, and also from hiPSCs, which are differentiated towards CD34+ cells and then to NK cells. There is an established NK cell line called NK-92. (b) Most relevant CAR-NK clinical trials use different sources of NK cells and different antigens, depending on the type of cancer.