Table 1.
Demographic, clinical, and biological characteristics of the entire cohort, and the groups with methylated and unmethylated MGMT. p-values derived from Mann–Whitney (MW) test or Fisher exact (FE) test analyzing differences between methylated and unmethylated MGMT.
| Variables | Entire Cohort | Methylated MGMT Population | Unmethylated MGMT Population | p-Values (MW/FE) |
|---|---|---|---|---|
| Number of patients | 123 | 67 | 56 | - |
| Gender | ||||
| -% females | 41.5 | 43.3 | 39.2 | 0.7150 |
| Age at diagnosis (years) | 0.8973 | |||
| -Mean | 60 | 62 | 58 | |
| -Range | (32,80) | (33,80) | (32,77) | |
| Overall Survival (months) | 0.1214 | |||
| -Mean | 20.2 | 22.4 | 17.6 | |
| -Median | 17.1 | 19.3 | 15.5 | |
| -Range | (2.7,72.8) | (2.7,71.6) | (2.7,72.8) | |
| Extent of Resection (#patients) | 0.4524 | |||
| -Complete | 45 | 27 | 18 | |
| -Partial | 78 | 40 | 38 | |
| Concomitant chemotherapy (#patients) | 0.3788 | |||
| -Complete | 110 | 58 | 52 | |
| -Incomplete | 13 | 9 | 4 | |
| Adjuvant chemotherapy (number of cycles) | 0.4435 | |||
| -Mean | 4 | 5 | 4 | |
| -Median | 5 | 5 | 4 | |
| -Range | (0,12) | (0,12) | (0,12) | |
| IDH1 mutation status | 1.0000 | |||
| -Mutated | 2 | 1 | 1 | |
| -Wild type | 93 | 51 | 42 | |
| -Unknown | 28 | 15 | 13 | |
| HAT rCBVmax | 0.4150 | |||
| -Mean | 9.77 | 9.49 | 10.10 | |
| -Median | 9.10 | 9.53 | 8.87 | |
| -Range | (3.39, 21.80) | (3.39, 16.93) | (3.49, 21.8) | |