Table 2.
Uniparametric Cox regression results for the entire cohort, and for the moderate- and high-vascular groups, using different proposed cut off thresholds: (I) the threshold proposed in the preliminary study [ref], (II) the median rCBVmax of the present study cohort, and (III) the combined threshold calculated with data of both populations (n = 214 patients).
| Association MGMT Methylation–Overall Survival | Number of Patients | HR [95% CI] | p-Value | |
|---|---|---|---|---|
| Analyzed thresholds | Entire cohort | 123 | 1.58 [1.06, 2.35] | 0.0247 * |
| (I) Th. proposed in [47] = 10.7 | Moderate rCBV | 80 | 1.70 [1.04, 2.79] | 0.0353 * |
| High rCBV | 43 | 1.36 [0.69, 2.67] | 0.3734 | |
| (II) Th. study cohort = 9.1 | Moderate rCBV | 61 | 2.40 [1.34, 4.31] | 0.0032 * |
| High rCBV | 62 | 1.04 [0.60, 1.80] | 0.9008 | |
| (III) Th. combined = 9.8 | Moderate rCBV | 71 | 2.01 [1.19, 3.41] | 0.0095 * |
| High rCBV | 53 | 1.09 [0.59, 2.00] | 0.7894 | |
* Significant p-values: < 0.05. Th.: threshold; HR: Hazard Ratio; CI: Confidence Interval.