Table 1.
Cancer-relevant genes up- or downregulated in HBE expressers.
| Gene Symbol | Ratio | Function | PMID | |
|---|---|---|---|---|
| KRT20 | 494 | Cytokeratin 20, associated with worse prognosis | 22493626 | |
| CEACAM6 | 11 | Member of the CEA family. Associated with worse prognosis | 24186057 | |
| CRISP3 | 10 | High expression correlates with malignancy | 30609035 | |
| ABCC2 | 10 | Multidrug resistance-associated protein 2 | 26499806 | |
| LRRC31 | 9 | Inhibitor of DNA repair | 33005030 | |
| MUC21 | 8.5 | Associated with incohesive growth of lung cancer | 31301084 | |
| CEACAM5 | 8 | Member of the CEA family. Driver of breast cancer metastasis | 29736411 | |
| TRIM72 | 8 | Lower expression predicts recurrence in colon cancer | 30852740 | |
| PNMT | 7.8 | Co-amplified with ERBB2 | 12727839 | |
| CXCL17 | 7 | Promotes proliferation and invasion of breast cancer cells | 28943434 | |
| AMER3 | −8.7 | Enhances β-catenin signaling in CRC | 24251807 | |
| KCNC1 | −8.8 | Its inhibition is associated with poor survival in seminoma | 34105734 | |
| INSM1 | −9.3 | In SCLC, low expression associated with better prognosis | 32118626 | |
| SLIT1 | −9 | Suppresses breast cancer growth | 18829537 | |
| RUNDC3A | −10.6 | High expression correlates with shorter survival in rectal cancer | 29050227 | |
| HDC | −13 | Increased expression associated with better survival | 31748740 | |
| ECEL1 | −14 | Associated with good prognosis in neuroblastoma | 12632073 | |
| CHRNA9 | −19 | High expression associated with poor survival in BRCA | 20953833 | |
| PCSK1 | −23 | Reduces growth of breast cancer cells | 11241161 | |
| NELL1 | −27 | Down-regulated in kidney cancer | 25726761 |
Top 20 genes showing significantly (p ≤ 0.05 by Student’s t test) higher (10 genes) or lower (10 genes) expression in the 15% upper percentile of B4GALNT2 expression. The red or green color indicates that the change has a putatively cancer-promoting (red) or cancer-restraining (green) effect, according to the literature search. The “PubMed Identification Number” (PMID) of the most relevant paper is indicated.