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. 2021 Oct 26;13(21):5365. doi: 10.3390/cancers13215365

Figure 3.

Figure 3

O-GlcNAcylation and metastasis. In non-small cell lung cancer (NSCLC), the epithelial mesenchymal transition (EMT) and transcriptional factors such as hypoxia-inducible factor-1α (HIF) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) are mediated via O-GlcNAcylation. In breast cancer, the activation of Krüppel-like factor 8 (KLF8) results in OGT activation.