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. 2021 Oct 20;13(21):5266. doi: 10.3390/cancers13215266

Table 4.

Changes in TNM classification over time.

Stage UICC/WHO 2003 ENSAT 2008 UICC 2020 (since 2010) AJCC, 8th Edition
I T1, N0, M0 T1, N0, M0 T1, N0, M0 T1, N0, M0
II T2, N0, M0 T2, N0, M0 T2, N0, M0 T2, N0, M0
III T1–2, N1, M0
T3, N0, M0
T1–2, N1, M0
T3–4, N0–1, M0
T1–2, N1, M0
T3–4, N0–1, M0
T3, N0, M0
T1/2, N1, M0
T4, N0, M0
T3/4, N1, M0
IV T1–4, N0–1, M1
T3, N1, M0
T4, N0–1, M0
T1–4, N0–1, M1 T1–4, N0–1, M1 T1–4, N0–1, M1

Definition of tumor stages: T1—tumor ≤ 5 cm; T2—tumor > 5 cm; T3—tumor infiltration in the surrounding tissue; T4—tumor invasion in the adjacent organs (ENSAT: also venous tumor thrombus in the vena cava/renal vein); N0—no positive lymph nodes; N1—positive lymph node(s); M0—no distant metastasis; M1—presence of distant metastasis.