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Model for the tumorigenic effects of TSPAN5 and the anti-tumorigenic effects of TSPAN5 depletion. DLC1 loss leads to increased TSPAN5 expression via MRTF-A transcriptional activation (left panel). Therapeutic knockdown of TSPAN5 results in OIS-induced inhibition of HCC growth via decreased actin polymerization and reduced MRTF/SRF target gene expression (right panel).
