TABLE 2.
Characteristics of rifampin-resistant M. tuberculosis strains isolated in Australia between 1990 and 1997
| Strain no. | Country of birth | First-line drug to which strain is resistanta | Rifabutin susceptibilityb | Rifampin MIC (μg/ml) | RFLP cluster | Mutated codon | Mutation |
|---|---|---|---|---|---|---|---|
| R1 | Timor | I, R | S | 32 | A | 522 | TCG→CAG |
| R2 | Timor | I, R | S | >256 | A | 522 | TCG→CAG |
| R3 | Timor | I, R, E | R | >256 | B | 526 | CAC→GAC |
| R4 | Timor | I, R, Pz | R | >256 | B | 526 | CAC→GAC |
| R5 | Timor | I, R, E (Int), Pz | R | Nonviable | B | 526 | CAC→GAC |
| R6 | Turkey | I, R | R | >256 | 526 | CAC→GAC | |
| R7 | Australia | R | R | >256 | 526 | CAC→TAC | |
| R8 | Ethiopia | I, R | R | >256 | 526 | CAC→TAC | |
| R9 | Vietnam | I, R, E | S | 32 | 526 | CAC→CTC | |
| R10 | Timor | I, R, Pz | S | >256 | 531 | TCG→TTG | |
| R11 | Vietnam | I, R, E | R | >256 | 531 | TCG→TTG | |
| R12 | Former Yugoslavia | I, R, E | R | >256 | 531 | TCG→TTG | |
| R13 | Vietnam | R | R | >256 | 531 | TCG→TTG | |
| R14 | Australia | I, R | R | >256 | 516 | GAC→GTC | |
| R15 | Turkey | I, R | S | >256 | 516 | GAC→GTC | |
| R16 | Vietnam | I, R, E | R | >256 | 572 | ATC→TTC | |
| R17 | Wales | I, R | S | >256 | |||
| R18 | Egypt | I, R, E | R | >256 | 526 | CAC→CGC | |
| R19 | Philippines | I, R | R | >256 | 531 | TCG→TTG | |
| R20 | Vietnam | I, R | Nonviable | Nonviable | 526 | CAC→TAC | |
| R21 | Unknown | I, R, E | R | >256 | 531 | TCG→TTG | |
| R22 | Korean | I, R, Pz | R | >256 | 531 | TCG→TTG | |
| R23 | Unknown | I, R | R | >256 | 531 | TCG→TTG | |
| R24 | Unknown | I, R, E | R | >256 | 516 | GAC→TAC | |
| R25 | Australia | I, R | R | >256 | 526 | CAC→TAC | |
| R26 | Philippines | I, R, E | Nonviable | Nonviable | 531 | TCG→TTG | |
| R27 | Laos | I, R | R | >256 | 531 | TCG→TTG | |
| R28 | Papua New Guinea | I, R | R | >256 | C | 531 | TCG→TTG |
| R29 | Vietnam | I, R | R | >256 | 531 | TCG→TTG | |
| R30 | Papua New Guinea | R | R | >256 | C | 531 | TCG→TTG |
| R31 | Philippines | I, R | R | >256 | 531 | TCG→TTG | |
| R32 | Korea | I, R, E | R | >256 | 531 | TCG→TTG | |
| R33 | Vietnam | I, R, E | R | >256 | 531 | TCG→TTG |
a
I, isoniazid; R, rifampin; E, ethambutol; Pz, pyrazinamide; Int, intermediate resistance.
b
S, sensitive; R, resistant.