Figure 1.

General depiction of the main molecular alterations and functional hallmarks involved in the development of preneoplastic (foci) and neoplastic (adenomas and carcinomas) lesions in widely-applied chemically induced models in mice. Strain-related and protocol-related variations should be considered. At late stages, molecular alterations are usually screened in a pool of neoplastic alterations, not considering if they are benign or malignant. CCl₄: carbon tetrachloride; DEN: diethylnitrosamine; PB: phenobarbital. The figure was composed with the aid of illustrations from the SMART-servier Medical Art available at https://smart.servier.com/ (accessed on 15 January 2021).