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In vitro permeation and retention (expressed as total amount of agent permeated or accumulated per unit membrane area) of ketoconazole (KTZ) from hydrogel (H) and organogel (O2) formulations with pure drug or combination of drug and tea tree oil (TTO) in membrane imitating human skin attained after 24 h; C—commercial topical preparation with KTZ. Values are expressed as means ± SD of six replicates; p ˂ 0.05.
