Table 3.
Drug content, pH, particle size, and viscosity of prepared PLU® F-127 hydrogels and PLO organogels containing KTZ (H KTZ, O1 KTZ, O2 KTZ, O3 KTZ), KTZ and TTO (H KTZ TTO, O1 KTZ TTO, O2 KTZ TTO, O3 KTZ TTO), placebo gels (H, O1–O3), and commercially available product (C). Values are expressed as means ± SD of six replicates.
| Formulation Code | Drug Content (%) |
pH | Particles Size (µm) |
Viscosity * (mPa∙s) |
|---|---|---|---|---|
| C | 97.5 ± 1.5 | 6.40 ± 0.02 | 37 ± 14 | 5920 ± 69 |
| H | - | 6.80 ± 0.01 | - | 2128 ± 40 |
| H KTZ | 92.1 ± 0.2 | 6.80 ± 0.01 | 63 ± 42 | 3142 ± 85 |
| H KTZ TTO | 90.4 ± 1.1 | 6.60 ± 0.02 | 38 ± 27 | 23,548 ± 153 |
| O1 | - | 6.70 ± 0.01 | - | 19,861 ± 127 |
| O1 KTZ | 96.4 ± 1.2 | 6.80 ± 0.01 | 62 ± 41 | 21,652 ± 78 |
| O1 KTZ TTO | 96.8 ± 1.3 | 6.60 ± 0.01 | 36 ± 24 | 23,399 ± 176 |
| O2 | - | 6.70 ± 0.01 | - | 6041 ± 82 |
| O2 KTZ | 95.8 ± 1.0 | 6.70 ± 0.01 | 58 ± 38 | 8498 ± 105 |
| O2 KTZ TTO | 96.3 ± 1.8 | 6.60 ± 0.01 | 48 ± 26 | 18,995 ± 96 |
| O3 | - | 6.60 ± 0.01 | - | 11,829 ± 74 |
| O3 KTZ | 91.0 ± 0.7 | 6.60 ± 0.01 | 63 ± 39 | 16,250 ± 124 |
| O3 KTZ TTO | 95.8 ± 1.7 | 6.50 ± 0.01 | 55 ± 26 | 21,255 ± 160 |
* Viscosity was measured at the shear rate 6.00 s−1 at 25 °C.