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. 2021 Oct 20;22(21):11326. doi: 10.3390/ijms222111326

Table 5.

Models of KTZ release from designed formulations and commercially available product (C).

Formulation Code Kinetic Models
Zero-Order Kinetics First-Order Kinetics Higuchi Model Korsmeyer–Peppas Model
R 2 K0 R 2 KI R 2 KH R 2 KKP n
C 0.987 0.266 0.937 0.197 0.853 0.808 0.992 0.712 0.631
H KTZ 0.980 0.262 0.942 0.180 0.942 0.819 0.971 0.638 0.584
H KTZ TTO 0.995 0.591 0.915 0.211 0.953 1.843 0.979 0.694 0.716
O1 KTZ 0.870 0.070 0.718 0.078 0.846 0.225 0.796 0.194 0.562
O1 KTZ TTO 0.989 0.392 0.921 0.186 0.959 1.233 0.975 0.627 0.609
O2 KTZ 0.988 0.203 0.902 0.160 0.978 0.645 0.968 0.570 0.529
O2 KTZ TTO 0.992 0.555 0.907 0.228 0.963 1.745 0.971 0.797 0.753
O3 KTZ 0.980 0.054 0.853 0.077 0.952 0.173 0.927 0.230 0.826
O3 KTZ TTO 0.977 0.144 0.968 0.133 0.921 0.446 0.976 0.445 0.524