Table 6.
Antifungal activity of prepared PLU® F-127 hydrogels and PLO organogels containing KTZ (H KTZ, O1 KTZ, O2 KTZ, O3 KTZ), KTZ and TTO (H KTZ TTO, O1 KTZ TTO, O2 KTZ TTO, O3 KTZ TTO),and controls: placebo gels (H, O1–O3), KTZ 2% in DMSO, TTO 5% in DMSO, and commercially available product (C). Values are expressed as means ± SD of six replicates.
| Formulation Code | Name of the Strain | ||
|---|---|---|---|
|
C. albicans ATCC 10231 |
C. parapsilosis ATCC 22019 |
C. krusei ATCC 6528 |
|
| Zone of Inhibition (mm) | |||
| C | 28.3 ± 0.6 | 39.5 ± 0.8 | 27.0 ± 1.1 |
| DMSO | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| TTO 5%/DMSO | 25.3 ± 0.5 | 26.0 ± 1.5 | 21.8 ± 1.9 |
| KTZ 2%/DMSO | 26.0 ± 0.9 | 50.8 ± 1.0 | 39.8 ± 0.4 |
| H | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| H KTZ | 36.8 ± 1.9 | 37.2 ± 1.7 | 28.5 ± 1.9 |
| H KTZ TTO | 42.2 ± 0.8 | 50.5 ± 0.8 | 30.5 ± 1.4 |
| O1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| O1 KTZ | 35.2 ± 1.0 | 35.5 ± 0.5 | 28.0 ± 1.7 |
| O1 KTZ TTO | 39.7 ± 1.6 | 46.3 ± 1.0 | 28.5 ± 1.0 |
| O2 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| O2 KTZ | 34.0 ± 0.6 | 35.0 ± 0.6 | 27.0 ± 0.8 |
| O2 KTZ TTO | 38.5 ± 0.8 | 45.7 ± 0.8 | 27.5 ± 0.5 |
| O3 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| O3 KTZ | 26.3 ± 1.4 | 32.3 ± 1.4 | 25.7 ± 1.3 |
| O3 KTZ TTO | 37.3 ± 0.8 | 42.3 ± 1.3 | 26.8 ± 1.0 |