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. 2021 Nov 3;13(21):5516. doi: 10.3390/cancers13215516

Figure 1.

Figure 1

Pharmacological inhibition of epigenetic chromatin modifiers inhibits melanoma growth in short-term survival assays. (A). Schematic illustration of the druggable screening approach using 32 different epigenetic regulators with 2 different melanoma cell lines (M14 and SKMEL-28). (B–I). Indicated melanoma cell lines were treated with different concentrations of various epigenetic regulators for 5 days and analyzed for survival using the MTT assay. Relative cell survival is plotted relative to vehicle-treated cells. Data represent the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns = not significant.