Figure 2.

Overexpression of BRD7/9, BRD2/3, and EZH2 in melanoma samples is correlated with poor prognosis. (A). List of compounds that inhibited melanoma cell growth and their epigenetic targets. (B). Indicated patient melanoma datasets were analyzed for the shown epigenetic regulators using Oncomine. Gene upregulation in patient’s melanoma samples relative to expression in normal skin using Oncomine-Talantov melanoma patient dataset is shown. (C). Immunohistochemical analysis of the expression of indicated epigenetic regulators using the Human Protein Atlas dataset. Relative quantity staining for each of the epigenetic regulators are shown. (D). Survival analysis (three year) of melanoma patients based on the high and low expression of the epigenetic regulators using Human Protein Atlas datasets is shown.