Skip to main content
. 2021 Nov 3;13(21):5516. doi: 10.3390/cancers13215516

Figure 4.

Figure 4

Transcriptome-wide mRNA expression profiling revealed that TP-472 treatment leads to downregulation of several extracellular matrix (ECM) proteins. A375 cells were treated with either DMSO, 5 μM TP-472, or 10 μM TP-472 for 24 h, after which RNA sequencing was performed. (A). Heatmap showing the top 100 genes exhibiting altered expression after 24 h of TP-472 treatment. (B). Volcano plot showing the top 100 genes exhibiting altered expression after treatment. (C). Reactome-based functional pathways analysis identified pathways that were significantly activated or suppressed in A375 cells treated with TP-472. (D). Reactome-based functional pathways revealed that several genes associated with ECM organization were downregulated.