Figure 1.

Hunting down liver metastasis in colorectal cancer patients by radiogenomics. The figure shows a comprehensive view of metastatic niche formation phases. Reasonably, the different phases of metastatic niche formation (each one represented by a puzzle piece in the figure) could be detected by radiogenomics approaches in the near future. The references included in the figure show related manuscript with information about tumor cell extravasation [34,35], neoangiogenesis [34,35,36,37,38,39,40,41,42,43,44,45,46,47], immunosurveillance evasion [44,47,48,49,50,51,52,53] and tumor growth [41] that could be theoretically translated to metastatic niche detection. Created with BioRender.com.