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. 2021 Nov 3;13(21):5523. doi: 10.3390/cancers13215523

Table 2.

Expression levels, fold change (FC), p-values, and rank of importance of the genes discriminating relapsing ALK+ and non-relapsing ALK+ tumors using microarray, high-throughput qPCR, and RNA sequencing data.

Microarray HG-U133-Plus2.0 Fluidigm Data RNAseq Kallisto/Sleuth DE
Mean Log 2 Intensity Mean (-Delta)Cq Wilcoxon Correlation Microarray-Fluidigm Sleuth Wald Test Mean Expression (tpm)
ProbeSet GeneSymbol NR R FC
R vs. NR		 logFC
R vs. NR		 p Value Adjusted
p Value
(BH)		 Mean
No_Relapse		 Mean
Relapse		 FC
R vs. NR		 logFC
R vs. NR		 p Value Adjusted
p Value
(BH)		 Pearson
Correlation
r		 r² p Value Corresp. ENSG p Value Adjusted
p Value
(BH)		 b (Effect Size ~ logFC Estimator) R vs. NR Mean
No_Relapse		 Mean
Relapse
228471_at ANKRD44 7.71 8.76 2.07 1.05 1.08 × 10−3 3.11 × 10−2 0.4 1.09 1.61 0.69 8.97 × 10−2 1.01 × 10−1 0.86 0.74 1.98 × 10−15 ENSG00000065413.20 1.08 × 10−2 1.55 × 10−1 0.55
210031_at CD247 7.93 9.07 2.21 1.14 2.10 × 10−3 4.53 × 10−2 ENSG00000198821.11 3.76 × 10−4 2.59 × 10−2 0.9 30.21 54.51
222043_at CLU 9.4 10.47 2.09 1.07 1.59 × 10−3 3.87 × 10−2 5.21 5.9 1.61 0.69 6.67 × 10−2 8.12 × 10−2 0.88 0.77 1.04 × 10−16 ENSG00000120885.22 2.05 × 10−2 2.17 × 10−1 0.56
236717_at FAM179A 6.31 8.07 3.38 1.76 3.62 × 10−5 3.52 × 10−3 −1.70 −0.16 2.9 1.54 2.61 × 10−3 1.07 × 10−2 0.97 0.93 9.46 × 10−29 ENSG00000189350.13 6.80 × 10−5 3.64 × 10−3 1.23 24.44 58.53
205718_at ITGB7 7.13 8.6 2.77 1.47 1.78 × 10−3 4.14 × 10−2 −0.36 1.07 2.7 1.43 5.35 × 10−3 1.34 × 10−2 0.97 0.95 7.59 × 10−31 ENSG00000139626.16 1.55 × 10−4 1.88 × 10−2 1 22.92 47.71
1558459_s_at LOC401320 5.47 6.49 2.03 1.02 1.64 × 10−9 1.13 × 10−5 −1.51 −1.02 1.4 0.49 6.26 × 10−2 7.82 × 10−2 0.62 0.38 1.71 × 10−5
218202_x_at MRPL44 3.45 5.69 4.73 2.24 1.08 × 10−36 1.55 × 10−32 1.29 1.39 1.07 0.1 1.23 × 10−1 1.32 × 10−1 0.21 0.05 7.81 × 10−2 ENSG00000135900.4 NA NA NA
213733_at MYO1F 8.71 9.75 2.06 1.04 2.51 × 10−5 2.75 × 10−3 0.68 1.65 1.95 0.96 2.43 × 10−3 1.07 × 10−2 0.91 0.83 1.15 × 10−18 ENSG00000142347.19 6.03 × 10−5 1.14 × 10−2 0.51 146.59 229.13
212259_s_at PBXIP1 6.74 7.74 2 1 2.49 × 10−3 4.99 × 10−2 0.88 1.72 1.79 0.84 3.67 × 10−2 5.51 × 10−2 0.95 0.9 2.43 × 10−25 ENSG00000163346.17 1.90 × 10−4 1.99 × 10−2 0.59 15.53 26.77
206060_s_at PTPN22 7.49 8.84 2.53 1.34 6.31 × 10−4 2.29 × 10−2 1.39 2.52 2.18 1.13 4.35 × 10−3 1.22 × 10−2 0.93 0.87 3.21 × 10−22 ENSG00000134242.16 2.70 × 10−5 1.79 × 10−3 0.9 43.82 93.55
208010_s_at PTPN22 5.99 7.35 2.55 1.35 1.18 × 10−3 3.26 × 10−2 1.39 2.52 2.18 1.13 4.35 × 10−3 1.22 × 10−2 0.87 0.75 8.39 × 10−16
236539_at PTPN22 7.34 8.45 2.16 1.11 1.49 × 10−3 3.74 × 10−2 1.39 2.52 2.18 1.13 4.35 × 10−3 1.22 × 10−2 0.94 0.89 9.00 × 10−24
218394_at ROGDI 5.22 6.32 2.13 1.09 3.09 × 10−9 1.78 × 10−5 −3.38 −2.75 1.55 0.63 6.50 × 10−3 1.54 × 10−2 0.76 0.58 2.13 × 10−10 ENSG00000067836.13 7.75 × 10−4 3.77 × 10−2 0.42 6.88 10.24
227552_at SEPT1 6.36 7.52 2.23 1.15 2.32 × 10−3 4.82 × 10−2 −0.50 0.68 2.26 1.18 5.05 × 10−2 6.89 × 10−2 0.93 0.87 3.74 × 10−22 ENSG00000180096.12 1.51 × 10−3 5.48 × 10−2 0.64
223044_at SLC40A1 10.78 12.03 2.38 1.25 2.57 × 10−4 1.38 × 10−2 1.19 2.54 2.55 1.35 1.39 × 10−3 7.20 × 10−3 0.94 0.89 5.92 × 10−24 ENSG00000138449.11 1.21 × 10−1 4.94 × 10−1 −0.46
244716_x_at TMIGD2 6.92 8.89 3.93 1.97 1.42 × 10−10 1.28 × 10−7 −2.28 −0.76 2.86 1.52 3.30 × 10−2 5.13 × 10−2 0.74 0.55 1.04 × 10−9 ENSG00000167664.8 4.47 × 10−4 2.80 × 10−2 1.31 19.25 37.27
226997_at ADAMTS12 6.88 5.79 0.47 −1.08 3.61 × 10−4 1.68 × 10−2 −0.78 −1.46 0.63 −0.68 4.15 × 10−2 5.84 × 10−2 0.91 0.82 5.00 × 10−19 ENSG00000151388.11 4.53 × 10−4 2.80 × 10−2 −0.56 5.49 3.14
ADAMTS12 ENSG00000281690.2 2.84 × 10−2 2.54 × 10−1 −0.45 7.05 4.54
224694_at ANTXR1 8.75 6.95 0.29 −1.80 7.56 × 10−5 6.01 × 10−3 1.14 −0.17 0.41 −1.30 7.37 × 10−3 1.66 × 10−2 0.96 0.91 2.24 × 10−26 ENSG00000169604.20 1.15 × 10−5 1.14 × 10−3 −1.18 14.29 4.45
204345_at COL16A1 8.15 6.98 0.45 −1.17 1.16 × 10−3 3.24 × 10−2 0.78 0.05 0.6 −0.73 5.30 × 10−2 7.00 × 10−2 0.94 0.88 6.02 × 10−23 ENSG00000084636.18 5.14 × 10−3 1.08 × 10−1 −0.75
221730_at COL5A2 10.87 9.71 0.45 −1.16 6.60 × 10−4 2.33 × 10−2 2.75 1.95 0.57 −0.80 3.85 × 10−2 5.59 × 10−2 0.92 0.85 1.32 × 10−20 ENSG00000204262.14 5.87 × 10−3 1.13 × 10−1 −0.54
225681_at CTHRC1 11.62 10.05 0.34 −1.57 4.40 × 10−4 1.89 × 10−2 1.39 0.07 0.4 −1.32 3.89 × 10−3 1.17 × 10−2 0.97 0.94 1.69 × 10−30 ENSG00000164932.13 8.87 × 10−8 3.25 × 10−4 −0.78 29.99 13.22
202450_s_at CTSK 10.12 8.8 0.4 −1.32 1.37 × 10−3 3.59 × 10−2 2.25 1.28 0.51 −0.97 1.34 × 10−2 2.32 × 10−2 0.96 0.92 1.14 × 10−26 ENSG00000143387.14 NA NA NA
201893_x_at DCN 12.14 10.87 0.42 −1.27 1.37 × 10−3 3.59 × 10−2 3.98 2.75 0.43 −1.22 3.78 × 10−3 1.17 × 10−2 0.95 0.9 2.71 × 10−25 ENSG00000011465.18 8.81 × 10−5 1.37 × 10−2 −1.01 319.12 132.97
211896_s_at DCN 12.13 10.72 0.37 −1.42 1.08 × 10−3 3.11 × 10−2 3.98 2.75 0.43 −1.22 3.78 × 10−3 1.17 × 10−2 0.94 0.88 3.10 × 10−23
211813_x_at DCN 11.66 10.12 0.34 −1.55 4.38 × 10−4 1.89 × 10−2 3.98 2.75 0.43 −1.22 3.78 × 10−3 1.17 × 10−2 0.93 0.86 1.51 × 10−21
201325_s_at EMP1 8.84 7.83 0.5 −1.01 8.35 × 10−4 2.70 × 10−2 1.88 1.04 0.56 −0.84 3.78 × 10−3 1.17 × 10−2 0.91 0.83 9.38 × 10−20 ENSG00000134531.10 3.03 × 10−4 2.36 × 10−2 −0.58 78.54 40.11
201324_at EMP1 10.77 9.74 0.49 −1.03 8.68 × 10−5 6.61 × 10−3 1.88 1.04 0.56 −0.84 3.78 × 10−3 1.17 × 10−2 0.92 0.85 1.76 × 10−20
209955_s_at FAP 8.28 6.44 0.28 −1.84 5.71 × 10−4 2.21 × 10−2 0.86 −0.81 0.31 −1.67 8.08 × 10−4 5.35 × 10−3 0.98 0.95 1.23 × 10−32 ENSG00000078098.14 9.08 × 10−5 4.08 × 10−3 −1.25 46.2 14.03
211719_x_at FN1 12.69 11.33 0.39 −1.36 2.04 × 10−4 1.18 × 10−2 4.68 3.17 0.35 −1.51 2.12 × 10−4 2.54 × 10−3 0.98 0.96 5.68 × 10−34 ENSG00000115414.21 1.45 × 10−5 1.27 × 10−3 −1.18 680.6 193.53
214701_s_at FN1 6.29 4.67 0.33 −1.62 5.11 × 10−7 1.50 × 10−4 4.68 3.17 0.35 −1.51 2.12 × 10−4 2.54 × 10−3 0.73 0.53 3.20 × 10−9
210495_x_at FN1 12.29 10.62 0.31 −1.67 7.05 × 10−5 1.07 × 10−3 4.68 3.17 0.35 −1.51 2.12 × 10−4 2.54 × 10−3 0.98 0.96 3.57 × 10−34
216442_x_at FN1 12.33 10.65 0.31 −1.69 9.99 × 10−5 1.35 × 10−3 4.68 3.17 0.35 −1.51 2.12 × 10−4 2.54 × 10−3 0.98 0.97 1.58 × 10−35
212464_s_at FN1 12.32 10.62 0.31 −1.69 1.09 × 10−5 1.41 × 10−3 4.68 3.17 0.35 −1.51 2.12 × 10−4 2.54 × 10−3 0.98 0.96 1.53 × 10−34
225481_at FRMD6 8.43 7.29 0.45 −1.14 4.17 × 10−4 1.84 × 10−2 0.31 −0.58 0.54 −0.89 1.19 × 10−2 2.23 × 10−2 0.94 0.88 7.77 × 10−22 ENSG00000139926.16 8.55 × 10−5 4.08 × 10−3 −0.80 26.78 47.71
225464_at FRMD6 8.41 7.27 0.45 −1.14 3.71 × 10−4 1.69 × 10−2 0.31 −0.58 0.54 −0.89 1.19 × 10−2 2.23 × 10−2 0.93 0.87 1.20 × 10−20
227070_at GLT8D2 8.2 6.95 0.42 −1.25 2.01 × 10−3 4.44 × 10−2 −0.78 −1.69 0.53 −0.91 2.54 × 10−2 4.09 × 10−2 0.94 0.89 7.62 × 10−22 ENSG00000120820.12 5.54 × 10−5 3.20 × 10−3 −0.71 15.03 7.28
227059_at GPC6 8.15 6.18 0.25 −1.97 2.46 × 10−5 2.75 × 10−3 −0.81 −2.77 0.26 −1.96 1.09 × 10−4 2.54 × 10−3 0.97 0.94 9.60 × 10−30 ENSG00000183098.11 NA NA NA
201035_s_at HADH 7 5.97 0.49 −1.02 4.44 × 10−11 4.56 × 10−8 −0.70 −0.86 0.89 −0.16 2.42 × 10−1 2.48 × 10−1 0.55 0.3 2.93 × 10−5 ENSG00000138796.17 2.17 × 10−2 2.24 × 10−1 −0.21
226218_at IL7R 9.7 8.17 0.34 −1.54 3.19 × 10−4 1.58 × 10−2 1.58 0.49 0.47 −1.09 2.98 × 10−3 1.12 × 10−2 0.95 0.91 1.27 × 10−25 ENSG00000168685.15 4.03 × 10−4 2.69 × 10−2 −0.59 73.03 39.19
205798_at IL7R 8.99 7.41 0.33 −1.59 6.31 × 10−4 2.29 × 10−2 1.58 0.49 0.47 −1.09 2.98 × 10−3 1.12 × 10−2 0.91 0.83 1.33 × 10−19
227140_at INHBA 9.26 6.5 0.15 −2.76 1.09 × 10−5 1.41 × 10−3 0.08 −1.94 0.25 −2.01 2.82 × 10−4 2.54 × 10−3 0.96 0.91 2.79 × 10−26 ENSG00000122641.11 3.05 × 10−5 8.21 × 10−3 −1.64 9.2 2.09
204686_at IRS1 6.61 5.45 0.45 −1.16 9.09 × 10−5 1.27 × 10−3 −1.31 −1.77 0.72 −0.47 7.18 × 10−2 8.50 × 10−2 0.77 0.59 1.12 × 10−10 ENSG00000169047.5 1.37 × 10−4 1.76 × 10−2 −0.50 10.16 5.97
204682_at LTBP2 7.22 6.04 0.44 −1.18 2.44 × 10−3 4.92 × 10−2 −0.08 −0.98 0.53 −0.91 5.45 × 10−2 7.00 × 10−2 0.45 0.2 1.03 × 10−3 ENSG00000119681.12 5.46 × 10−5 1.09 × 10−2 −1.02 13.28 5.61
201069_at MMP2 9.55 7.61 0.26 −1.94 2.12 × 10−3 4.57 × 10−2 2.23 0.66 0.34 −1.57 1.34 × 10−2 2.32 × 10−2 0.98 0.96 7.23 × 10−33 ENSG00000087245.13 3.56 × 10−3 8.81 × 10−2 −1.22
203936_s_at MMP9 7.78 6.22 0.34 −1.56 2.24 × 10−3 4.72 × 10−2 0.94 −0.58 0.35 −1.52 5.01 × 10−3 1.33 × 10−2 0.96 0.91 7.85 × 10−26 ENSG00000100985.7 6.81 × 10−3 1.22 × 10−1 −1.03
203939_at NT5E 7.42 5.96 0.36 −1.46 6.32 × 10−5 5.20 × 10−3 0.05 −0.96 0.5 −1.01 1.44 × 10−3 7.20 × 10−3 0.95 0.9 1.05 × 10−24 ENSG00000135318.12 6.37 × 10−5 1.15 × 10−2 −0.62 6.52 3.31
204992_s_at PFN2 8.19 6.8 0.38 −1.39 1.30 × 10−4 8.64 × 10−3 ENSG00000070087.14 9.83 × 10−3 1.47 × 10−1 −0.46
205479_s_at PLAU 8.91 7.07 0.28 −1.84 3.01 × 10−5 3.13 × 10−3 1.82 0.5 0.4 −1.32 2.50 × 10−4 2.54 × 10−3 0.98 0.95 6.36 × 10−32 ENSG00000122861.16 1.91 × 10−4 1.99 × 10−2 −0.95 5.89 2.46
210809_s_at POSTN 12.88 10.81 0.24 −2.07 1.19 × 10−4 8.13 × 10−3 1.42 −0.38 0.29 −1.80 3.89 × 10−3 1.17 × 10−2 0.94 0.88 2.33 × 10−23 ENSG00000133110.15 2.52 × 10−4 2.17 × 10−2 −1.37 292.37 75.76
1555778_a_at POSTN 11.22 8.86 0.19 −2.36 2.37 × 10−4 1.29 × 10−2 1.42 −0.38 0.29 −1.80 3.89 × 10−3 1.17 × 10−2 0.91 0.82 3.07 × 10−19
202975_s_at RHOBTB3 8.07 7.06 0.5 −1.01 9.35 × 10−4 2.88 × 10−2 1.33 0.97 0.78 −0.36 3.26 × 10−1 3.26 × 10−1 0.67 0.44 1.49 × 10−7 ENSG00000164292.13 3.70 × 10−2 2.88 × 10−1 −0.33
212110_at SLC39A14 9.15 7.88 0.41 −1.28 1.43 × 10−4 9.34 × 10−3 1.48 0.78 0.61 −0.70 1.17 × 10−2 2.23 × 10−2 0.94 0.89 1.03 × 10−23 ENSG00000104635.15 7.67 × 10−5 1.28 × 10−2 −0.74 24.89 11.29
212354_at SULF1 10.36 8.44 0.26 −1.92 1.82 × 10−4 1.10 × 10−2 2.23 0.5 0.3 −1.73 2.30 × 10−4 2.54 × 10−3 0.98 0.95 1.47 × 10−32 ENSG00000137573.14 6.56 × 10−8 3.25 × 10−4 −1.34 131.96 37.09
212344_at SULF1 9.24 7.15 0.24 −2.09 1.06 × 10−4 7.35 × 10−3 2.23 0.5 0.3 −1.73 2.30 × 10−4 2.54 × 10−3 0.95 0.9 4.63 × 10−25
212353_at SULF1 10.33 8.19 0.23 −2.14 6.30 × 10−5 5.20 × 10−3 2.23 0.5 0.3 −1.73 2.30 × 10−4 2.54 × 10−3 0.98 0.97 2.01 × 10−36
206506_s_at SUPT3H 6.28 5.26 0.49 −1.02 2.36 × 10−5 5.22 × 10−4 −1.11 −1.26 0.9 −0.15 1.39 × 10−1 1.45 × 10−1 0.43 0.18 1.36 × 10−3 ENSG00000196284.17 2.45 × 10−2 2.37 × 10−1 −0.20
203083_at THEM4 7.5 6.46 0.39 −1.35 1.86 × 10−5 2.19 × 10−3 −10.85 −18.80 4.04 × 10−3 −7.95 1.14 × 10−1 1.25 × 10−1 0.68 0.46 8.14 × 10−8 ENSG00000159445.13 3.52 × 10−3 8.78 × 10−2 −0.32
1553118_at THBS2 9.82 8.47 0.49 −1.04 1.93 × 10−3 4.33 × 10−2 2.3 1.35 0.52 −0.95 1.83 × 10−2 3.05 × 10−2 0.98 0.95 3.75 × 10−32 ENSG00000186340.16 3.38 × 10−5 8.78 × 10−3 −1.00 70.74 28.41
219410_at TMEM45A 8.55 7.1 0.37 −1.45 7.23 × 10−4 2.49 × 10−2 −0.67 −1.71 0.49 −1.04 7.99 × 10−3 1.71 × 10−2 0.97 0.93 9.69 × 10−29 ENSG00000181458.10 2.32 × 10−2 2.30 × 10−1 −0.19
220968_s_at TSPAN9 5.94 4.73 0.43 −1.21 5.79 × 10−14 9.26 × 10−11 −0.13 −0.68 0.68 −0.55 9.13 × 10−3 1.87 × 10−2 0.71 0.5 1.11 × 10−8 ENSG00000011105.14 5.59 × 10−4 3.15 × 10−2 −0.45 11.05 6.43
243526_at WDR86 6.21 4.96 0.42 −1.25 4.04 × 10−7 1.24 × 10−4 −3.20 −3.93 0.61 −0.72 7.69 × 10−2 8.87 × 10−2 0.64 0.41 5.71 × 10−7 ENSG00000187260.16 1.87 × 10−2 2.07 × 10−1 −0.41