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Model of Stat1 in TNFR1 signal transduction. TNFR1-recruited Stat1 can form a complex with TRADD. By binding to TRADD, Stat1 prevents TRADD from further interacting with RIP and TRAF2 without affecting the association between TRADD and FADD. Consequently, the TRADD-mediated NF-κB activation process is blocked. Thus, Stat1 promotes TNF-α-induced apoptosis, presumably due to its inhibitory effect on NF-κB activation.
