Figure 5.

Technical validation of serum PCa spectral library using an independent PCa patient cohort of pre- (n = 29) and post-radiotherapy (n = 14) patients. (A) Coefficient of variance (CV) across all the validation samples. (B) Dynamic range of the PCa serum proteome based on the rank by abundance of the log10 mean intensity of all identified proteins in the validation cohort. (C) Dynamic ranges of individual proteins detected in the validation cohort based on the ratio of the maximum and minimum log10 protein intensities. (D) Number of transitions, peptides and proteins identified at 1% FDR across the validation cohort.