Figure 2.

Scheme of ADAR1, 2 and 3 protein domains. All ADARs have an evolutionarily conserved catalytic deaminase domain at their C termini and dsRBD domains with nuclear localization signals (two dsRBDs in ADAR2 and ADAR3 and three in ADAR1 isoforms) closer to the N termini. There are two isoforms of ADAR1: ADAR1p150, which has two Z domains and nuclear export signal (NES); and ADAR1p110, which has one Z domain and lacks the NES. ADAR3 possesses an R domain. Amino acid lengths of ADARs are shown in brackets

Z: Z-DNA binding domain; dsRBD: double stranded RNA binding domain; DM: deaminase domain; NES: nuclear export signal; NLS: nuclear localization signal; R: Arginine-rich single-stranded RNA (ssRNA)-binding domain (R domain).