Figure 1.

Concentration dependence of the zero-shear rate (extrapolated) viscosity of 14 IgG1 and IgG4P mAbs at 50, 100, 150, and 175 mg/ml in 20 mM sodium acetate at pH 5.5. The zero-shear viscosity was calculated by extrapolating viscosity at different shear-rate to zero. Omalizumab IgG1 cannot be concentrated >100 mg/ml and omalizumab IgG4P cannot be concentrated past 20 mg/ml