Figure 2.
Correlation of experimental zero-shear viscosity at 150 mg/mL with measured kD values for (a) IgG1 and (b) IgG4P. The solid lines indicate linear correlation of all 13 mAbs (including cetuximab and excluding omalizumab since it could not be concentrated 150 mg/ml)) and R is its linear correlation coefficient. Cetuximab is the only high viscosity mAb for which we were able to measure viscosity at 150 mg/ml concentrations for both IgG1 and IgG4P. The dashed lines indicate linear correlation excluding cetuximab, which has the highest viscosity (55.7 cP for IgG1 and 264.6 cP for IgG4P) and R’ is its linear correlation coefficient