Table 5.
Diffusion interaction parameter (kD) (0–20 mg/ml) and experimental viscosity of IgG1, IgG4P, and IgG4P CH3 swapped mutants. The viscosity is averaged from different shear rates. The zero-shear viscosity is calculated by extrapolating to zero shear rate using a polynomial fit. All mAbs except Cetuximab exhibited a Newtonian behavior for viscosity
| mAbs | IgG1 |
IgG4P |
IgG4P CH3 swapped mutants |
||||||
|---|---|---|---|---|---|---|---|---|---|
| kD (ml/g) | Experimental viscosity (cP) at 150 mg/ml (Averaged) | zero-shear viscosity (cP) at 150 mg/ml (Extrapolated) | kD (ml/g) | Experimental viscosity(cP) at 150 mg/ml (Averaged) | zero-shear viscosity(cP) at 150 mg/ml (Extrapolated) | kD (ml/g) | Experimental viscosity (cP) at 150 mg/ml (Averaged) | zero-shear viscosity (cP) at 150 mg/ml |
|
| (Extrapolated) | |||||||||
| Cetuximab | −10.6 | 40.9 | 55.7 | −26.49 | 205.6 | 264.6 | −12.24 | 72.6 | 75 |
| Atezolizumab | 11.56 | 21.8 | 22.3 | −7.17 | 49.9 | 53 | −3.81 | 13.81 | 14.01 |
| Trastuzumab | 14.68 | 9.2 | 9.3 | −4.45 | 8.7 | 8.8 | 4.77 | 7.7 | 7.9 |
| Golimumab | 9.31 | 7.5 | 7.6 | −3.88 | 8.6 | 8.7 | 8.5 | 7.3 | 8.9 |