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GEF-H1 amplification in cancers. A. Analysis of ARHGEF2 copy number variations in the TCGA PanCancer Atlas set of 32 studies [139] using cBioPortal [140] revealed 6 cancer types with > 5% frequency of gene amplification. B. For uterine corpus endometrial carcinoma, ARHGEF2 amplification in 40 out of 529 patients (7.6%) was associated with significantly reduced overall survival (p < 0.0001, Mantel-Cox test)
