Figure 7.
(a) Maximum detachment force (Fmax) expressed in millinewtons (mN); (b) work of mucoadhesion (Wad) expressed in microjoules per tissue area unit (µJ/cm2) of hydrogels with a binary mixture of lyophilized extract of S. baicalensis radix and chitosan 80:500 (in weight ratio 1:1) (F1–F2), placebo formulations (P1–P2), and controls (Control-1 cellulose paper; Control-2 commercial oromucosal gel) in contact with excised porcine cheek (mean ± S.D., n = 5); * represents substantial differences with p ≤ 0.05, ** with p ≤ 0.01 and *** with p ≤ 0.001 in comparison to Control-1; † and †† symbolize significant differences with p ≤ 0.05 and p ≤ 0.01 in comparison to placebo formulations.