Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Main ECM remodelling processes in cancer in respect to normal ECM.
| Increased ECM Deposition | ECM Degradation | Altered Post-Translational Modifications |
|---|---|---|
| ↑Fibronectin, collagens I, III, IV | ↑ECM degradation ↑Creation of bioactive molecules (matrikines) ↑Release of growth factors ↑Angiogenesis ↑ Metastasis |
↑LOX activity ↑ECM stiffness ↑Mechanosignalling ↑Interstitial fluid pressure ↓ Impeded immune cell activity |
↑ - increased; ↓ - decreased.
