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. 2021 Nov 9;15(1):191–206. doi: 10.1080/19336896.2021.1991771

Table 1.

Pro and anti-inflammatoy microglial targets in CDJ

Pro-inflammatory

  • IL-1

  • (IL)-1β

  • Toll-like-receptor (TLR)-4 agonist lipopolysaccharide (LPS)

  • TLR-3 agonist Poly I: C

  • Tumour necrosis factor-α (TNFα)

  • CSF-1 R

  • STAT and NFkβ signiling pathways
Anti-inflammatory

  • IL-4

  • IL-13

  • Immune complexes

  • IL- 1 R ligands

  • IL-10

  • TGF-β

  • Glucocorticoids

  • Endocannabinoid type 2 receptor (CB2)

  • Histamine receptors

  • Nuclear receptors PPARs-y

  • Trk-A receptors

  • C–C Motif Chemokine Ligand 2 (CCL2)

  • Prostaglandin E2 (PGE2)

  • miRNA-146a